Dr. Upasana Bedi Chanana

Ex-Present affiliation:

Assistant Professor (Contract),
Department of Biotechnology,
All India Institute of Medical Sciences,
Ansari Nagar,
New Delhi-110029

Email ID: upasanabchanana@aiims.edu

Phone(O): -

Education: 

Teaching and Research Experience: 

1. Young Scientist (May’2016 – Present)
Chromatin Remodeling Laboratory, School of Life Sciences,
Jawaharlal Nehru University, New Delhi - 110069

2. Research Associate (October’2014 – January’2016)
Molecular Oncology Laboratory, National Institute of Immunology,
New Delhi – 110069

3. Graduate Student (July’2010 – June’2014)
Department of Molecular Oncology, University of Göttingen, Germany

Courses Completed: 

• “Certificate Programme in Bioinformatics and Computational Biology” held at Sri Venkateswara College, Delhi University, New Delhi, India from September 2007 – December 2007.

• Industrial Training in the Analytical Department, Research & Development Centre at Ranbaxy Laboratories Limited, Gurgaon, India from 22^nd May’ 2007 to 13^th July’ 2007.

• Worked in the project titled “Cloning of Signal Transduction genes in Mycobacterium tuberculosis” held at Sri Venkateswara College, Delhi University, New Delhi, India in 2007-2008.

• Internship in the project report “Construction of disruption cassette for RTA2 gene of Candida albicans” at School of Life Sciences, Jawaharlal Nehru University, New Delhi, India from 27^th May – 22^nd July’ 2009.

• “BioAssays & BioEfficacy Models, Tools, Targets & Technologies, Paradigm Shift in New Drug Discovery & Biotechnology Research” held at Jawaharlal Nehru University, New Delhi, India from 25^th July – 5^th August’ 2016.

Conferences/Meetings Attended:
• 9^th EMBL Conference Transcription and Chromatin (28-31 August’ 2010) at EMBL Heidelberg, Germany

• International Symposium on “Chromatin Changes in Differentiation and Malignancies” (12-14 September’ 2011) held at Justus-Liebig University, Giessen, Germany

• Poster presentation at EMBL Conference Stem Cells in Cancer and Regenerative Medicine (29 August-1 September’ 2012) at EMBL Heidelberg, Germany

• 2^nd International Meeting on “Molecular-Based Treatment of GI Cancer” (1-2 March’ 2013) at University Hospital Centre, Göttingen

Fellowships, Honors, Awards and Prizes:

1. Young Scientist Fellowship from Department of Health Research, Ministry of Health and Family Welfare, India.

2. Department of Biotechnology- Research Associate fellowship (DBT-RA)
(2015-16).

3. ‘Summa cum laude’ grade for Ph.D. dissertation and defense.

4. Erasmus Mundus (EURINDIA) fellowship to pursue Ph.D. at University of Göttingen, Germany.

5. Dr. G. Pande Medal (2008-09) for securing the Highest CGPA in M.Sc. I Year examination at IIT Roorkee.

6. Dr. G. Pande Medal (2009-10) for the girl student obtaining Highest CGPA in M.Sc. Final Year Examination at IIT Roorkee.

7. Dr. A.N. Khosla Medal (2009-10) for obtaining Highest CGPA in M.Sc./M.Tech. (Science) courses at IIT Roorkee.

8. Smt. Sushilavati Khosla Medal (2009-10) for the girl student obtaining Highest CGPA in M.Sc./ M.Tech (Science) courses at IIT Roorkee.

9. All India 19th rank in IIT Joint Admission for M.Sc. (JAM).

Publications:

Sankari Nagarajan†, Upasana Bedi†, Anusha Budida, Feda H. Hamdan, Vivek Kumar Mishra, Zeynab Najafova, Wanhua Xie, Malik Alawi, Daniela Indenbirken, Stefan Knapp, Cheng-Ming Chiang, Adam Grundhoff, Vijayalakshmi Kari, Christina H. Scheel, Florian Wegwitz and Steven A. Johnsen. (2016) BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells. Nucleic Acids Research 45(6):3130-3145. (Ϯ Equal contribution)

Upasana Bedi, Andreas Scheel, Magali Hennion, Yvonne Begus-Nahrmann, Josef Ruschoff, Steven A. Johnsen (2014) SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms. Oncogene. 34(4):465-73

Upasana Bedi, Vivek Kumar Mishra, David Wasilewski, Christina Scheel, Steven A. Johnsen (2014) Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer. Oncotarget 5, 2016–2029

Tanja Prenzel, Frank KramerϮ, Upasana BediϮ, Sankari Nagarajan, Tim Beissbarth, Steven A. Johnsen (2012) Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene. Epigenetics & chromatin 5(1):13. ( Ϯ Equal contribution)

Swati Srivastava, Upasana Bedi and Partha Roy (2012) Synergistic actions of insulin-sensitive and Sirt1-mediated pathways in the differentiation of mouse embryonic stem cells to osteoblast. Molecular and cellular endocrinology 361(1-2):153–164.

Sankari Nagarajan, Tareq Hossan, Malik Alawi, Zeynab Najafova, Daniela Indenbirken, Upasana Bedi, Hanna Taipaleenmaki, Isabel Ben-Batalla, Marina Scheller, Sonja Loges, Stefan Knapp, Eric Hesse, Cheng-Ming Chiang, Adam Grundhoff, Steven A. Johnsen (2014) Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription. Cell Reports 8, 460–469

Zeynab Najafova, Roberto Tirado-Magallanes, Malayannan Subramaniam, Tareq Hossan, Geske Schmidt, Sankari Nagarajan, Simon J. Baumgart, Vivek Kumar Mishra, Upasana Bedi, Eric Hesse, Stefan Knapp, John R. Hawse and Steven A. Johnsen. (2017) BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire. Nucleic Acids Research 45(1):127-141

Stefan Werner, Benedikt Brors, Julia Eick, Elsa Marques, Vivian Pogenberg, Annabel Parret, Dirk Kemming, Antony W. Wood, Henrik Edgren, Hans Neubauer, Thomas Streichert, Sabine Reithdorf, Upasana Bedi, Irene Baccelli, Manfred Jucker, Roland Eils, Tanja Fehm, Andreas Trumpp, Steven A. Johnsen, Juha Klefstrom, Matthias Wilmanns, Volkmar Mueller, Klaus Pantel, Harriet Wikman (2015) Suppression of Early Hematogenous Dissemination of Human Breast Cancer Cells to Bone Marrow by Retinoic Acid–Induced 2. Cancer Discovery 5(5):506-19

Ketki Patne, Radhakrishnan Rakesh, Vijendra Arya, Upasana Bedi Chanana, Ramesh Sethy, Pynskhem Bok Swer and Rohini Muthuswami. (2017) BRG1 and SMARCAL1 transcriptionally co-regulate DROSHA, DGCR8 and DICER in response to doxorubicin-induced DNA damage. BBA – Gene Regul Mech 1860(9):936-951

Grants:

1. Young Scientist Grant from DHR, Ministry of Health and Family Welfare for 3 years (2016-2019).